Molecular Status of BRAF Mutation in Epithelial Ovarian Cancer: An Analysis of 57 Cases in the Northeast of Iran

Background & Objective: Epithelial ovarian cancer (EOC) is the most prevalent type of cancer. Previous studies have elucidated different pathways for progress this malignancy. The mutation in B-Raf proto-oncogene, serine/threonine kinase (BRAF) gene, a member MAPK/ERK signaling pathway, plays role EOC. current study aimed to determine frequency BRAF V600E serous and mucinous tumors, including borderline carcinoma subtypes.Methods: A total 57 formalin-fixed paraffin-embedded samples, tumors (SBTs), low-grade carcinomas (LGSCs), high-grade (HGSCs), (MBTs), carcinomas, normal tissues were collected. was analyzed using polymerase chain reaction (PCR) sequencing.Results: While 40% SBT harbor mutation, we found no invasive (P=0.017). Also, there only 1 MBT carcinomas. In addition, control group.Conclusion: frequent but not It seems that 2 exist development epithelial neoplasms: one other Our supports hypothesis. rare neoplasms.